Effect of polymyxin B on the synthesis of prodigiosin and its precursors in Serratia marcescens.
نویسندگان
چکیده
منابع مشابه
Inhibitory effect of polymyxin B on prodigiosin biosynthesis in Serratia marcescens.
Sir: Prodigiosin or prodigiosin-like antibiotic pigments are tripyrrole compounds synthesized by Serratia marcescens, Vibrio psychroerythrus, Pseudomonas magnesorubra and Alteromonas rubra as well as several genera of actinomycetes.1.2) Although the structures of several of the pigments are known, the site of localization and biosynthesis is less than clear.3,4) Studies of inhibition of prodigi...
متن کاملEffect of gramicidin A and valinomycin on prodigiosin production by non-proliferating Serratia marcescens.
different concentrations of gramicidin A. O 10 /Mg/ml, A 5 ^g/ml, å¡ 20 ^g/ml, ® 40 ^g/ml, ffl 40 ^g of gramicidin A/ml with only L-proline, A 40 fig of gramicidin A/ml alone and v is 40 jug of gramicidin A/ml and 300 fig of polymyxin B/ml without L-proline. Prodigiosin is a secondary metabolite produced by some strains of Serratia marcescens and other taxonomically unrelated bacteria. Some aut...
متن کاملProdigiosin synthesis in mutants of Serratia marcesens.
Morrison, D. A. (Harvard College, Cambridge, Mass.). Prodigiosin synthesis in mutants of Serratia marcescens. J. Bacteriol. 91:1509-1604. 1966.-Exchange of biosynthetic intermediates through the culture medium was used to characterize several hundred new color mutants of Serratia marcescens. The general scheme of prodigiosin synthesis as a bifurcated pathway, in which monopyrrole and bipyrrole ...
متن کاملDefects in prodigiosin formation by L-forms of Serratia marcescens.
An L-form of Serratia marcescens has previously been shown incapable of producing the red pigment, prodigiosin, characteristic of the parent bacteria. Mutants of S. marcesens, unable to form one or the other of the two prodigiosin precursors, 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde or 2-methyl-3-n-amylpyrrole, were used to test the nature of the L-form defect. The L-forms failed to form suffi...
متن کاملReview of Prodigiosin, Pigmentation in Serratia marcescens
Prodigiosins, a family of natural red pigments characterized by a common pyrrolylpyrromethane skeleton, are produced by various bacteria that first characterized from Serratia marcescens. This pigment is a promising drug owing to its reported characteristics of having antifungal, immunosuppressive and anti-proliferative activity. From an industrial point of view to obtain optimal conditions to ...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 36 11 شماره
صفحات -
تاریخ انتشار 1983